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. 2010 Jan 27;285(13):9716–9728. doi: 10.1074/jbc.M109.073981

FIGURE 8.

FIGURE 8.

Trypsin has little effect on INa inhibited by HOCl incubation. A, shown is a representative time course recordings of INa at −100 mV from hENaC-expressing oocytes perfused by 1 mm HOCl-ND96 (●) or incubated in 100 μm HOCl-ND96 for 2 h (○), then perfused with trypsin (Try, 2 μm) and amiloride (Ami, 10 μm). B, group data showed trypsin increased INa to control levels in oocytes perfused with HOCl-ND96. Incubation (Incu) with HOCl-ND96 for 2 h greatly inhibited INa, and perfusion with trypsin had little effect on INa of these oocytes (mean ± S.E., n = 11 for HOCl-perfused and 5 for HOCl-incubated oocytes; *, p < 0.05).