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. Author manuscript; available in PMC: 2010 Mar 22.
Published in final edited form as: Anesthesiology. 2008 Dec;109(6):1077–1084. doi: 10.1097/ALN.0b013e31818dac9c

Fig. 4.

Fig. 4

Photomicrograph of effect of systemic administered gabapentin (GBP) on phosphorylated cyclic adenosine monophosphate response element binding protein (pCREB) activation in the locus coeruleus. Normal and spinal nerve-ligated (SNL) rats received saline (A-C) or GBP (50 mg/kg intravenous; D-F) while conscious or during 2% isoflurane anesthesia, and then brainstems were collected 30 min after injection for dopamine-β-hydroxylase (green) and pCREB (red) staining. In the SNL group (B, C, E, and F), photomicrographs of brainstems ipsilateral to nerve injury are presented. Scale bar = 50 μm.