Table 1.
Properties of phasic and tonic GABAergic currents recorded from different cell types in wildtype and Gabrd−/− mice
Genotype | Cell type | n | IPSC frequency (Hz) | IPSC amplitude (pA) | THIP-induced Itonic (pA) |
---|---|---|---|---|---|
WT | Pyramidal | 8 | 18.8 ± 3.3 | 34.8 ± 2.9 | 19.8 ± 3.7 |
Perisomatic-targeting interneuron | 3 | 32.5 ± 6.5 | 40.2 ± 7.6 | 13.9 ± 6.2 | |
Dendritic-targeting interneuron | 4 | 12.9 ± 8.6 | 31.2 ± 3.4 | 23.0 ± 9.4 | |
Non-pyramidal projection neuron | 2 | 14.3 ± 2.4 | 53.4 ± 4.7 | 27.4 ± 15.1 | |
δ KO | Pyramidal | 5 | 17.2 ± 1.8 | 42.7 ± 2.6 | 25.8 ± 5.9 |
Perisomatic-targeting interneuron | 3 | 18.2 ± 3.8 | 40.5 ± 3.6 | 8.3 ± 2.4 | |
Dendritic-targeting interneuron | 4 | 10.0 ± 1.7 | 37.1 ± 3.7 | 12.7 ± 4.5 | |
Non-pyramidal projection neuron | 3 | 8.6 ± 0.5 | 38.4 ± 6.7 | 2.8 ± 5.7 |