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. Author manuscript; available in PMC: 2010 Sep 4.
Published in final edited form as: Nature. 2010 Mar 4;464(7285):104–107. doi: 10.1038/nature08780

FIGURE 1. PMN [Ca2+]i responses to MTD.

FIGURE 1

Rhabdomyosarcoma-derived125125 MTD (1.2μg/ml protein) induces Ca2+ store depletion (a) and Ca2+ influx (a, b) in human PMN. (*p=0.01, t-test). c, PMN serially exposed to MTD and GRO-α (CXCL1) exhibit heterologous desensitization. d, PMN stimulated with GRO-α or MTD show equal store release by ionomycin. e, PMN show homologous desensitization of [Ca2+]i responses to MTD. f, Systemic injection of MTD increases rat PMN responses to PAF. Traces with error bars are from ≥3 experiments, other traces are exemplary. Traces may be displaced temporally for clarity.