Table 3.
Overlapping Expression of Phenotypic Markers/Antigens by Individual Myeloid Cell Types
| Marker | Inflammatory Monocyte
|
Resident Monocyte
|
TAM
|
TEM
|
Dendritic cell
|
Mast cell
|
Neutrophil
|
Eosinophil
|
MDSC
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M | H | M | H | M | H | M | H | M | H | M | H | M | H | M | H | M | H | |
| CD45 | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + |
| CD11b | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + |
| F4/80* | + | − | + | − | + | − | + | − | + | − | − | ND | − | − | ? | ND | +/− | ND |
| CD11c | +/− | + | +/− | + | +/− | − | − | − | + | + | − | − | − | − | − | − | +/− | ND |
| Mrc1 | −/low | ND | + | ND | −/low | ND | + | ND | ND | ND | − | − | − | ND | − | − | ND | ND |
| Tie2 | − | −/low | low | low | − | − | + | + | ND | ND | − | ND | − | +/− | + | ND | − | ND |
| Gr1 | + | X | − | X | −/low | X | − | X | low | X | − | X | + | X | + | X | + | X |
| CXCR4 | + | + | + | + | + | + | ND | ND | + | + | ND | + | + | + | + | + | + | ND |
| VEGFR1† | ND | ND | ND | ND | + | + | ND | ND | + | + | − | + | + | + | + | + | + | + |
M indicates mouse; H, human; +, expression of antigen has been confirmed; low, expression of antigen low or limited to a fraction of the cells; −, antigen not expressed +/−, positive expression reported by some investigators and negative expression by others; ND, not determined; X, antigen does not exist for this species.
*
The human homolog of murine F4/80 is known as “EGF-like module containing mucin-like hormone receptor (EMR)−1.”
†
VEGFR1 expression has been confirmed on monocytes, but it is not known whether expression levels are different between inflammatory and resident subsets.