Figure 1.

Generation of the human survivin promoter-driven luciferase reporter-transgenic (SPlucTg) mice. A: Diagram of the structure of the transgene cassette. Four primers used in PCR to determine genotype of the transgenic mouse are shown. B: Representative genotyping results for the transgenic mice. C: The luciferase expression profile in genotype-positive SPlucTg mice was determined by in vivo imaging. Red arrows indicate testes that show luciferase activity. ♂ indicates male mice; ♀, female mice.