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. 2010 Apr;176(4):1725–1734. doi: 10.2353/ajpath.2010.090209

Figure 3.

Figure 3

VEGF knockout (KO) in type II cells results in emphysema-like phenotype in 28- to 32-week-old SPC-VEGF KO mice. A: H&E staining of lung tissues shows enlarged alveolar spaces in SPC-VEGF-KO mice. B: Morphometric analysis with mean linear intercept, which was significantly lower (meaning more pronounced airspace enlargement) in SPC-VEGF-KO mice (n = 6) in comparison with wild-type (WT) littermates (n = 10). *P = 0.0420. C: Exterior appearance of representative lungs from SPC-VEGF-KO mice and wild-type littermates at the age of 28 to 32 weeks. D: Dynamic lung compliance was significantly higher in SPC-VEGF-KO mice (n = 6) in comparison with wild-type littermates (n = 10). *P = 0.004.