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. 2010 Apr;176(4):1725–1734. doi: 10.2353/ajpath.2010.090209

Figure 6.

Figure 6

VEGF knockout (KO) in type II cells increases caspase-dependent apoptosis in the alveolar wall in 7- to 10-week-old mice. A: Double immunofluorescent staining for activated (cleaved) caspase 3 (red) and Surfactant Protein B (SP-B) (green), showing increased number of activated caspase 3-positive type II cells (arrows) in SPC-VEGF-KO animals in both baseline and IIR conditions, in comparison with their wild-type littermates. Original magnification, ×1000. B: Western blotting showing total caspase 3 and cleaved (activated) caspase 3 in lung tissue lysates from different groups of animals.