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Inhibition of the proteasome pathway dramatically decreases serum CK levels in 7-week-old mdx mice. Blood samples from untreated (saline only) and Velcade-treated mdx mice were obtained by intracardiac punctures at 2 weeks of treatment. Each column represents the mean ± SE from four to seven animals. *P < 0.05 untreated (white bar) versus Velcade-treated (black bar) mdx mice.
