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. Author manuscript; available in PMC: 2010 Mar 22.
Published in final edited form as: Toxicol Pathol. 2009;37(7):969–982. doi: 10.1177/0192623309350475

Figure 1.

Figure 1

Photomicrographs of trichrome-stained renal sections from AST rats receiving combined treatment with estradiol and medroxyprogesterone acetate illustrate marked structural damage (grade 4+) including glomerular mesangiolysis and fibrinoid necrosis (A and B); glomerulosclerosis and periglomerular fibrosis (C and D); and vascular myointimal proliferation, sclerosis, and perivascular fibrosis (E and F). A full set of representative kidney sections from all treatment groups is available in the online supplement.