. Author manuscript; available in PMC: 2010 Mar 22.

Published in final edited form as: Toxicol Pathol. 2009;37(7):969–982. doi: 10.1177/0192623309350475

Table 1.

Cardiac weight and serum markers of renal toxicity.

	Sham (n = 10)	Ovx/npx (n = 5)	Intact/npx AST placebo (n = 10)	Ovx/npx AST placebo (n = 10)	Ovx/npx AST + E2 (n = 10)	Ovx/npx AST + E2 + spiro (n = 10)	Ovx/npx AST + E2 + dro 3mg (n = 10)	Ovx /npx AST + E2 + dro 9mg (n = 10)	Ovx/npx AST + E2 + dro 30mg (n = 10)	Ovx/npx AST + E2 + MPA (n = 10)
Heart weight (mg)	637 ± ll^a ^c	709 ± 21^a ^c	809 ± 11^c	922 ± 35^c	762 ± 20^a ^c	788 ± 18^c	838 ± 68^c	743 ± 32^a ^c	752 ± 16^a ^c	1082 ± 81
Heart weight/tibia length (mg/cm)	167 ± 3^a ^c	187 ± 6^a ^c	213 ± 3^c	242 ± 9^c	200 ± 5^a ^c	207 ± 5^c	221 ± 19^c	194 ± 8^a ^c	192 ± 4^a ^c	279 ± 21
Serum creatinine (mg/dL)	0.4 ± 0.01	0.5 ± 0.04	0.4 ± 0.02	0.4 ± 0.01	0.4 ± 0.01	0.4 ± 0.03	0.4 ± 0.02	0.3 ± 0.03	0.4 ± 0.02	0.4 ± 0.04
Serum urea (mg/dL)	59.1 ± 7	70.4 ± 6	41.2 ± 2	49 ± 2	55 ± 5	59 ± 8	50.4 ± 5	46.3 ± 2	62.1 ± 6	43.1 ± 5
Serum albumin (g/dL)	3.6 ± 0.30	3.5 ± 0.06	N.A.	3.2 ± 0.15^b	3.9 ± 0.17^a ^b ^c	4.0 ± 0.03^a ^b ^c	3.8 ± 0.09^a ^b ^c	3.9 ± 0.13^a ^b ^c	3.8 ± 0.16^a ^b ^c	2.7 ± 0.25^b

Note: Values are mean ± SEM. Significances:

p < .05 vs. ovx/npx AST placebo

p < .05 vs. intact/npx AST + placebo

p < .05 vs. ovx/npx AST + E2 + mpa

§ p < .05 vs. ovx/npx AST + E2

‡ < .05 vs ovx/npx

∥ p < .05 vs. ovx/npx and sham.

Abbreviations: AST, aldosterone salt treatment; MPA, medroxyprogesterone acetate; E2, 17β-estradiol; ovx, ovarectomy; npx, uni-nephrectomy; dro, drospirenone; spiro, spironolactone.