Skip to main content
. Author manuscript; available in PMC: 2010 May 19.
Published in final edited form as: Cell Host Microbe. 2009 Nov 19;6(5):482–492. doi: 10.1016/j.chom.2009.10.006

Fig 2. Salp15 antiserum enhances the protective capacity of OspA antibody.

Fig 2

(A) Spirochete burden in murine skin, heart and joints at day 21 post tick feeding. (B) Arthritis index of the murine joints at day 21 post tick feeding. (Horizontal lines represent the mean values of the spots. Results are pooled from at least three independent experiments.) (C) Histopathology of tarsal joints from mice infected with B. burgdorferi treated with different antibodies. Representative hematoxylin and eosin stained sections from naive control (no infection) (a., score of 0), normal rabbit serum control (b., score of 2.5), low dose of OspA Ab+Salp15Ab (c., score of 0.5), low dose of OspA Ab (d., score of 2.5), high dose of OspA Ab (e., score of 0), and Salp15 Ab (f., score of 1). Tarsal joints from mice treated with a low dose of OspA Ab +Salp15Ab (c.) and high dose of OspA Ab (e.) had the lowest average inflammation scores. (Scale bars = 1000 μm). Arrows shows the leukocytes infiltration and exudation of fibrin and leukocytes into the joint lumen. (D) Spirochete burden in ticks at day 7 post tick feeding. (Values represent the mean+ s.e.m of three independent experiments.) (E) Spirochete burden in mouse skin at day 3 post tick feeding. (F) Spirochete burden in skin at day 7 post tick feeding. Horizontal lines represent the mean values of the spots. Results are pooled from three independent experiments. * p < 0.05 and ** p < 0.01, when compare with the normal rabbit serum control group.