Table II.

Summary of cytokine modulation by C1q^a

	Summary of Cytokine Modulation by C1q
	C1q immobilized/bound to plate						C1q bound to late apoptotic cells
	Modulation of basal levels			Modulation of LPS-induced levels			Modulation of apoptotic cells only levels
	Monocytes	HMDMs	iDCs	Monocytes	HMDMs	iDCs	Monocytes	HMDMs	iDCs
IL-1β	ND	ND	ND	↓	↓	↓	–	–	–
TNF-α	↓	↓	↓	↓	↓	↓	–	↓	↑
IL-8	↓	↓	↓	↓	↓	–	ND	ND	ND
MIP-1α/CCL3	↓	↓	↓	↓	↓	–	–	–	↓
MCP-1/CCL2	↑	↓	↓	↑	↑	↓	↑	↑	↑
IL-6	↓	↑	↓	↑	↑	↓	–	–	–
IL-10	–	–	–	↑	↓	↓	↑	↑	↑

^aLevels of cytokines secreted by human monocytes, macrophages (HMDMs), and iDCs were measured by Luminex multiplex analysis. Significant increases (↑,↑) and decreases (↓,↓) in cytokine levels triggered by C1q for the conditions indicated are shown. Differences that did not reach statistical significance are noted (–). Data are representative of at least three individual experiments per condition. Bold (↑,↓, –) indicates a response different from that in monocytes.