Table 1. Allele frequencies in GD and control subjects for SNPs in the CTLA4 gene region in different populations.
| Populations | Combined | Shandong | |||||||||
| SNP | Allele | control (%) | case (%) | p Value | OR | OR (95%CI) | control (%) | case (%) | p Value | OR | OR (95%CI) |
| rs11571315 | A | 3063 (71.8) | 3890 (76.3) | 4.65×10−6 | 1.26 | 1.15–1.39 | 948 (71.2) | 1407 (76.4) | 0.0022 | 1.31 | 1.12–1.54 |
| G | 1201 (28.2) | 1206 (23.7) | 384 (28.8) | 435 (23.6) | |||||||
| rs4553808 | A | 3304 (86.7) | 4274 (88.6) | 0.0127 | 1.19 | 1.05–1.36 | 1109 (88.9) | 1575 (88.4) | 0.7068 | 0.95 | 0.76–1.20 |
| G | 506 (13.3) | 548 (11.4) | 139 (11.1) | 207 (11.6) | |||||||
| rs11571316 | C | 3048 (80.3) | 3714 (83.5) | 0.0004 | 1.25 | 1.11–1.39 | 984 (79.1) | 1106 (79.6) | 0.7842 | 1.03 | 0.85–1.24 |
| T | 748 (19.7) | 732 (16.5) | 260 (20.9) | 284 (20.4) | |||||||
| rs231775 | G | 2713 (70.5) | 2790 (74.8) | 9.39×10−5 | 1.24 | 1.12–1.38 | 849 (71.2) | 783 (75.7) | 0.0271 | 1.26 | 1.04–1.52 |
| A | 1135 (29.5) | 938 (25.2) | 343 (28.8) | 251 (24.3) | |||||||
| rs231777 | C | 3320 (86.1) | 4294 (87.8) | 0.0288 | 1.16 | 1.03–1.32 | 1109 (88.7) | 1603 (87.5) | 0.3449 | 0.89 | 0.71–1.11 |
| T | 536 (13.9) | 596 (12.2) | 141 (11.3) | 229 (12.5) | |||||||
| rs35219727 | G | 3500 (92.0) | 4485 (91.9) | 0.9792 | 1.00 | 0.85–1.17 | 1207 (96.9) | 1693 (92.9) | 1.30×10−5 | 0.42 | 0.29–0.61 |
| A | 306 (8.0) | 393 (8.1) | 39 (3.1) | 129 (7.1) | |||||||
| rs231779 | T | 2903 (69.2) | 3837 (75.2) | 2.81×10−9 | 1.35 | 1.23–1.48 | 875 (70.2) | 1409 (75.7) | 0.0019 | 1.32 | 1.12–1.55 |
| C | 1293 (30.8) | 1267 (24.8) | 371 (29.8) | 453 (24.3) | |||||||
| rs231723 | G | 3457 (72.4) | 3674 (76.5) | 2.55×10−5 | 1.24 | 1.13–1.36 | 945 (70.9) | 1455 (75.9) | 0.0038 | 1.29 | 1.10–1.51 |
| A | 1317 (27.6) | 1130 (23.5) | 387 (29.1) | 463 (24.1) | |||||||
| rs10197010 | A | 3259 (84.6) | 4193 (86.0) | 0.1129 | 1.11 | 0.99–1.25 | 1087 (87.1) | 1562 (86.3) | 0.5549 | 0.93 | 0.75–1.15 |
| C | 591 (15.4) | 685 (14.0) | 161 (12.9) | 248 (13.7) | |||||||
| rs231725 | A | 2431 (63.0) | 3329 (68.2) | 2.86×10−6 | 1.26 | 1.15–1.38 | 799 (64.0) | 1231 (67.6) | 0.0602 | 1.17 | 1.01–1.36 |
| G | 1427 (37.0) | 1553 (31.8) | 449 (36.0) | 591 (32.4) | |||||||
| rs11571302 | C | 3336 (77.8) | 4246 (81.6) | 2.29×10−5 | 1.26 | 1.14–1.40 | 992 (77.0) | 1563 (81.4) | 0.0052 | 1.31 | 1.10–1.55 |
| A | 952 (22.2) | 958 (18.4) | 296 (23.0) | 357 (18.6) | |||||||
| rs231729 | A | 2718 (63.2) | 3547 (68.2) | 2.61×10−6 | 1.25 | 1.15–1.36 | 824 (63.9) | 1298 (68.0) | 0.0244 | 1.20 | 1.04–1.40 |
| T | 1580 (36.8) | 1653 (31.8) | 466 (36.1) | 610 (32.0) | |||||||
| rs231730 | T | 3745 (86.5) | 4494 (87.4) | 0.2671 | 1.08 | 0.95–1.21 | 1166 (87.4) | 1638 (87.0) | 0.7745 | 0.97 | 0.78–1.19 |
| A | 583 (13.5) | 650 (12.6) | 168 (12.6) | 244 (13.0) | |||||||
| rs231731 | T | 3662 (85.0) | 4496 (86.4) | 0.0735 | 1.12 | 1.00–1.26 | 1111 (85.6) | 1644 (85.9) | 0.8254 | 1.02 | 0.84–1.25 |
| C | 648 (15.0) | 710 (13.6) | 187 (14.4) | 270 (14.1) | |||||||
| rs10932025 | G | 3663 (85.1) | 4510 (86.6) | 0.0677 | 1.12 | 1.00–1.26 | 1119 (86.2) | 1657 (86.5) | 0.8383 | 1.02 | 0.83–1.26 |
| C | 639 (14.9) | 700 (13.4) | 179 (13.8) | 259 (13.5) | |||||||
The p value with bold letters indicate those allele frequencies with significant differences between GD and normal subjects.