Table 1. Conservation of amino acids at positions identified by 3s mutant in HCV sequenced from genotype 1 patients.

Amino Acids	Genotypes					Comments
	1b	1a	1	1g	1c
Gly 260	178/1203	43/208	115/115	1/1	1/2	High frequency of D,A,Q at position 260 for 1b,High frequency of A,T,Q,M at position 260 for 1a
Val 284	140/1203	38/208	45/115	0/1	1/2	All non V positions were Ile
Leu 307	1200/1203	208/208	115/115	1/1	2/2	2 L to P changes AM401923, DQ492170,1 L to Q change DQ491971
Asp 320	1196/1203	208/208	115/115	0/1	1/2	3 D to E changes AF033364,AY808017, EF4075003D to G changes AM493473, DQ492132, DQ492178 1D to N change AY8080331G  =  AM910652
Tyr 325	1197/1203	208/208	115/115	1/1	2/2	2 Y to C changes AM401892, AM4019742 Y to D changes DQ491959, DQ4919651 Y to H change AF0333611 Y to N change DQ492001
Val 356	1198/1203	208/208	115/115	1/1	2/2	2 R to Q change1 R to W change2 R to L change
Gly 448	1097/1203	208/208	115/115	1/1	2/2	4 V to I changes AF033364, AY808017,EF407500 1 V to A change AU4022251 V to G change AM402246