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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Feb 13;20(7):2174–2177. doi: 10.1016/j.bmcl.2010.02.041

Table 1.

Structures and mAChR activities of analogues 8.

graphic file with name nihms181199u1.jpg
Cmpd Ar M1 IC50 (μM)a M2 IC50 (μM)a M3 IC50 (μM)a M4 IC50 (μM)a M5 IC50 (μM)a
6 graphic file with name nihms181199t1.jpg 3.2 >10 >10 >10 >10
8a graphic file with name nihms181199t2.jpg 0.96 ND 8.2 ND 2.3
8b graphic file with name nihms181199t3.jpg 0.82 ND 5.6 ND 1.3
8c graphic file with name nihms181199t4.jpg 2.9 6.9 >10 3.7 >10
8d graphic file with name nihms181199t5.jpg 2.1 ND >10 ND 3.5
8e graphic file with name nihms181199t6.jpg 0.35 ND 3.7 ND 0.83
8f graphic file with name nihms181199t7.jpg 3.2 ND >10 ND >10
8g graphic file with name nihms181199t8.jpg 2.9 >10 4.3 3.7 4.1
8h graphic file with name nihms181199t9.jpg 0.49 2.7 4.2 1.5 4.1
8i graphic file with name nihms181199t10.jpg 2.6 >10 >10 3.7 >10
8j graphic file with name nihms181199t11.jpg 4.7 >10 >10 >10 >10
a

IC50s are an average of three independent experiments using mAChR (CHO) cell lines. ND = not determined.