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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Exp Hematol. 2010 Jan 29;38(4):270–281. doi: 10.1016/j.exphem.2010.01.004

Figure 2. Treatment of mice with captopril following high-dose irradiation is radioprotective whereas treatment prior to irradiation has a radiosensitization effect.

Figure 2

Mice were untreated or were administered captopril (0.1 mg/kg/day) in their drinking water before and/or after exposure to 7.5 Gy 60Co gamma total body irradiation (TBI). (A) The percentage of mice surviving at 30 days is shown. Results represent a total of 16-20 mice per group. * p < 0.05 from untreated irradiated mice. ** p < 0.001 from untreated irradiated mice. (B) Graph of 30 day survival. (C) Time-dependent change in body weight in nonirradiated control mice or mice that received captopril in their drinking water before and/or after exposure to 7.5 Gy 60Co TBI. Data represent the change in body weight ± standard error (SEM). n = 20 mice per group). Statistical findings are noted in the text.