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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Exp Hematol. 2010 Jan 29;38(4):270–281. doi: 10.1016/j.exphem.2010.01.004

Figure 4. Effect of captopril on nucleated cell bone marrow reconstitution in irradiated mice.

Figure 4

Mice were 1) untreated irradiated, 6.0 Gy total body irradiation (TBI-control group), 2) pretreated with captopril (0.1 mg/kg/day) for 7 consecutive days before irradiation, or 3) irradiated and then given captopril (0.1 mg/kg/day) for 14 consecutive days. At days 5 and 14 postirradiation, femoral bone marrow cells were collected. (Panel A) Total number of nucleated leukocytes cells per femur postirradiation. The number of assayable multilineage and lineage specific colony-forming progenitor cells were determined from bone marrow cells collected at day 5 (Panel B) and day 14 (Panel C) postirradiation. Multipotential (CFU-GEMM), myeloid (CFU-GM, CFU-M), and erythroid (BFU-E) bone marrow colony forming cells were determined. For all panels, results represent means ± SEM of six mice. * p < 0.05, compared with TBI-treated group; † p < 0.05 compared with the captopril pretreatment-treated group. For comparison purposes the bone marrow cellularity of untreated nonirradiated mice was 20.37 × 106 nucleated leukocytes/femur (data not shown).