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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: J Thorac Cardiovasc Surg. 2009 Jul 25;139(4):1033–1040. doi: 10.1016/j.jtcvs.2009.05.032

Figure 1. Coronary microvascular response to serotonin in vitro.

Figure 1

A. Diameter of microvessels before pre-contraction. There was no difference in baseline vessel diameter among the groups (p=0.4).

B. Diameter of microvessels after pre-contraction. Vessels were pre-contracted with U46619, a thromboxane A2 analog. There was no difference among the groups prior to addition of serotonin (p=0.31).

C. Serotonin response of vessels harvested before CP-CPB with and without selective 5-HT1B receptor blocker, SB224289. SB224289 administered in the presence of 5HT to the pre-CP-CPB microvessels resulted in a response similar to the 5HT alone (p= 0.44).