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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: J Thorac Cardiovasc Surg. 2009 Jul 25;139(4):1033–1040. doi: 10.1016/j.jtcvs.2009.05.032

Figure 2. Serotonin-inducecd coronary microvascular response to 5-HT1B, PLC and PLA2 inhibitors in vitro.

Figure 2

A. Coronary microvascular response to serotonin demonstrates a relaxation response prior to cardiopulmonary bypass. After bypass the microvessels switched to a strong contraction response. After addition of a 5-HT1B receptor blocker (SB224289) the post bypass contraction response was significantly diminished. (* pre- to post-bypass p< 0.001) (+ post-bypass to post-bypass + antagonist p< 0.001).

B. Microvascular response to serotonin in the presence of the PLC inhibitor, Quinacrine and PLA2 inhibitor, U73122, prior to CP-CPB. (Quinacrine to 5HT alone p= 0.17 and U73122 to 5HT alone p= 0.38). Post-CP-CPB microvessels subjected to Quinacrine yielded a significant reduction in the contractile response as compared to the post-CP-CPB response with 5HT alone (* p< 0.001). The contractile response was not significantly changed when U73122 was applied to post-CP-CPB microvessels as compared to 5HT alone (p= 0.58).