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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Feb 6;20(7):2264–2269. doi: 10.1016/j.bmcl.2010.02.006

Table 2.

hS1P1 and S1P3 receptors activation on calcium mobilization Gi assay a

EC50 (nM) S1P1 S1P3
S1P 0.027 0.449
(S)-FTY720-P 0.012 0.134
(R)-FTY720-P 23.25 >5,000
(2’R)-3-P
isomer 1		 0.077 0.215
(2’R)-3-P
isomer 2		 0.344 >5,000
(2R, 2’S)-6 0.018 0.286
(2R, 2’R)-6 0.088 0.150
(2S, 2’R)-6 19.72 >5,000
(2S, 2’S)-6 13.65 >5,000
a

Assay performed as described in the Reference 19.