. Author manuscript; available in PMC: 2011 Apr 1.

Published in final edited form as: Bioorg Med Chem Lett. 2010 Feb 6;20(7):2264–2269. doi: 10.1016/j.bmcl.2010.02.006

Table 3.

hS1P1-S1P5 receptors activation on calcium mobilization Gq assay ^a

EC₅₀ (nM)	S1P1	S1P2	S1P3	S1P4	S1P5
(S)-FTY720-P	2.02	>5000	27.84	22.16	0.36
(R)-FTY720-P	>5000	>5000	16.06	136.70	1988.00
(2’R)-3-P isomer 1	1.95	>5000	18.75	5.39	0.33
(2’R)-3-P isomer 2	133.00	>5000	25.72	41.45	32.96
(2R, 2’S)-6	1.79	>5000	97.44	15.98	1.49
(2R, 2’R)-6	5.62	-	38.17	-	-
(2S, 2’S)-6	>5000	-	922.10	-	-

Assay performed as described in the Reference ¹⁹.