Table 3. Cox univariate analysis for metastasis-free survival.

	All patients (n=265)			pN0 patients (n=126)			pN+ patients (n=139)
Characteristics	HR	CI	P-value	HR	CI	P-value	HR	CI	P-value
Age (years)
<48	3.22	1.50–6.93		6.29	0.73–54.16		2.42	1.06–5.54
48–53	1.30	0.55–3.09		2.18	0.20–24.09		1.06	0.42–2.69
54–64	0.67	0.26–1.69		1.76	0.16–19.64		0.42	0.15–1.15
>64	1.00		<0.001	1.00		0.202	1.00		<0.001
Menopausal status
Pre	1.65	0.97–2.82		3.60	0.93–13.97		1.40	0.77–2.52
Post	1.00		0.066	1.00		0.064	1.00		0.271
Surgical tumour size
pT1	1.00			1.00			1.00
⩾pT2	3.64	1.83–7.25	0.001	1.80	0.50–6.44	0.365	3.57	1.50–8.45	0.004
Histological type
Lobular	1.00			1.00			1.00
Ductal	0.95	0.47–1.95	0.895	1.99	0.25–15.76	0.516	0.81	0.38–1.75	0.592
Lymph node status
pN0	1.00
pN+	3.67	1.85–7.30	<0.001
Histological grade a
1	1.00			1.00
2	6.06	0.82–44.93		0.80	0.09–7.21
3	10.90	1.46–81.46	0.004	1.71	0.19–15.44	0.494			NAb
ER and PgR status
ER and PgR positive	1.00		0.001	1.00		0.261	1.00		<0.001
ER and/or PgR negative	2.47	1.44–4.23		0.31	0.04–2.42		3.43	1.89–6.23
Gabarapl1 status
Log (1/gabarapl1)c	4.96	2.43–10.12	<0.001	1.32	0.20–8.92	0.777	14.96	4.80–46.60	<0.001

Abbreviations: HR=hazard ratio; CI=confidence interval; ER= oestrogen receptor; PgR=progesterone receptor.

P-values correspond to Cox regression model.

^aHistological grade defined only in ductal carcinoma.

^bNo events in histological grade 1 tumour subset.

^cHR for an increase of one log (1/gabarapl1).