Table 4. Cox multivariate analysis of metastasis-free survival.
|
All patients (n=253)
|
pN0 patients (n=122)
|
pN+ patients (n=131)
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristics | HR | CI | P-value | HR | CI | P-value | HR | CI | P-value |
| Basal model | |||||||||
| Surgical tumour size | |||||||||
| pT1 | 1.00 | 1.00 | 1.00 | ||||||
| ⩾pT2 | 3.00 | 1.49–6.00 | 0.002 | 1.81 | 0.51–6.48 | 0.360 | 3.59 | 1.51–8.54 | 0.004 |
| Lymph node status | |||||||||
| pN0 | 1.00 | ||||||||
| pN+ | 2.93 | 1.46–5.88 | 0.002 | ||||||
| ER and PgR status | |||||||||
| ER and PgR positive | 1.00 | 1.00 | 1.00 | ||||||
| ER and/or PgR negative | 2.15 | 1.24–3.75 | 0.007 | 0.35 | 0.04–2.80 | 0.325 | 2.92 | 1.56–5.46 | 0.001 |
| Basal model and gabarapl1 | |||||||||
| Surgical tumour size | |||||||||
| pT1 | 1.00 | 1.00 | 1.00 | ||||||
| ⩾pT2 | 2.68 | 1.33–5.42 | 0.006 | 1.62 | 0.44–5.95 | 0.464 | 3.21 | 1.34–7.70 | 0.009 |
| Lymph node status | |||||||||
| pN0 | 1.00 | ||||||||
| pN+ | 3.12 | 1.54–6.309 | 0.002 | ||||||
| ER and PgR status | |||||||||
| ER and PgR positive | 1.00 | 1.00 | 1.00 | ||||||
| ER and/or PgR negative | 1.73 | 0.96–3.12 | 0.007 | 0.21 | 0.02–2.27 | 0.200 | 2.41 | 1.26–4.62 | 0.008 |
| Gabarapl1 status | |||||||||
| Log (1/gabarapl1)a | 3.63 | 1.48–8.93 | 0.005 | 3.79 | 0.32–45.64 | 0.294 | 5.65 | 1.84–17.29 | 0.002 |
Abbreviations: HR=hazard ratio; CI=confidence interval; ER= oestrogen receptor; PgR=progesterone receptor.
All values were adjusted by age.
a
HR for an increase of one log /gabarapl1).
P-values correspond to Cox regression model.