Table 2. The most ideal combination of HPV DNA types giving maximum sensitivity and specificity for detection of CIN2+ for 14 HR-HPV DNA types.
| HPV type in assay | # types | TP | FN | FP | TN | Sensitivity | Specificity |
|---|---|---|---|---|---|---|---|
| 0 | 0 | 0 | 16 | 0 | 297 | 0.000 | 1.000 |
| HPV16 | 1 | 5 | 11 | 3 | 294 | 0.313 | 0.990 |
| HPV16-33 | 2 | 8 | 8 | 4 | 293 | 0.500 | 0.987 |
| HPV16-33-18 | 3 | 11 | 5 | 6 | 291 | 0.688 | 0.980 |
| HPV16-33-18-51 | 4 | 12 | 4 | 6 | 291 | 0.750 | 0.980 |
| HPV16-33-18-51-66 | 5 | 13 | 3 | 9 | 288 | 0.813 | 0.970 |
| HPV16-33-18-51-66-56 | 6 | 14 | 2 | 12 | 285 | 0.875 | 0.960 |
| HPV16-33-18-51-66-56-45 | 7 | 15 | 1 | 19 | 278 | 0.938 | 0.936 |
| HPV16-33-18-51-66-56-45-35 | 8 | 16 | 0 | 27 | 270 | 1.000 | 0.909 |
| HPV16-33-18-51-66-56-45-35-58 | 9 | 16 | 0 | 28 | 269 | 1.000 | 0.906 |
| HPV16-33-18-51-66-56-45-35-58-68 | 10 | 16 | 0 | 29 | 268 | 1.000 | 0.902 |
| HPV16-33-18-51-66-56-45-35-58-68-31 | 11 | 16 | 0 | 31 | 266 | 1.000 | 0.896 |
| HPV16-33-18-51-66-56-45-35-58-68-31-39 | 12 | 16 | 0 | 33 | 264 | 1.000 | 0.889 |
| HPV16-33-18-51-66-56-45-35-58-68-31-39-52 | 13 | 16 | 0 | 37 | 260 | 1.000 | 0.875 |
| HPV16-33-18-51-66-56-45-35-58-68-31-39-52-59 | 14 | 16 | 0 | 42 | 255 | 1.000 | 0.859 |
Abbreviations: TP=true positive; FN=false negative; FP=false positive; TN=true negative.