Table 3. Distribution of genotypes according to response.

		Responder (CR+PR+SD> 6 months)	Non- responder (SD <6 months)
	Total n (%)	n (%)	n (%)	P-value
All	60 (100)	45 (75)	15 (25)	—
				0.28
TS-5-UTR
2R/2R	10 (16)	5 (50)	5 (50)
2R/3R	31 (52)	23 (74)	8 (26)
3R/3R	19 (32)	15 (79)	4 (21)
TS-5-UTR+G/C SNP				0.056
A) 2C/2C,2C/3C, 2GC/3C,2C/3G,3C/3C	35 (61)	23 (66)	12 (34)
B) 2GC/3G,3G/3C, 3G/3G	22 (39)	16 (73)	6 (27)
TS-31494del6				0.26
−6/−6	6 (10)	5 (83)	1 (17)
−6/+6	26 (43)	21 (81)	5 (19)
+6/+6	28 (47)	19 (68)	9 (32)
GSTP1				0.007
AA	20 (33)	10 (50)	10 (50)
AG	34 (56)	30 (88)	4 (12)
GG	6 (10)	5 (83)	1 (17)
GSTT1				0.1
Present	46 (77)	34 (74)	12 (26)
Null	14 (23)	11 (78)	3 (22)
GSTM1				0.1
Present	25 (42)	21 (84)	4 (16)
Null	35 (58)	24 (68)	11 (31)
GSTA1				0.32
CC	20 (33)	15 (75)	4 (25)
CT	28 (47)	21 (75)	7 (25)
TT	13 (21)	9 (69)	4 (31)
XPD				0.30
AA	23 (38)	18 (78)	5 (22)
AC	30 (51)	21 (70)	9 (30)
CC	7 (11)	6 (86)	1 (14)
XRCC1				0.33
GG	27 (44)	20 (74)	7 (30)
GA	26 (43)	20 (77)	6 (23)
AA	7 (11)	5 (71)	2 (29)
ERCC1–118				0.36
CC	9 (15)	6 (67)	3 (33)
CT	25 (42)	21 (84)	4 (16)
TT	25 (42)	17 (68)	8 (32)
UGT1A1				0.38
5/6	1 (1.6)	—	1 (100)
6/6	29 (48)	22 (76)	7 (24)
6/7	28 (47)	21 (75)	7 (25)
7/7	2 (3.3)	1 (50)	1 (50)
MTHFR-677				0.17
CC	26 (43)	18 (69)	8 (31)
CT	23 (38)	17 (74)	6 (26)
TT	11 (18)	10 (91)	1 (9)
MTHFR-1298				0.33
AA	31 (52)	22 (71)	9 (29)
AC	23 (38)	18 (78)	5 (22)
CC	6 (10)	5 (83)	1 (17)

Abbreviations: CR=complete response; PR=partial remission; SD=stable disease; UTR=untranslated region.