Table 4. Adjusted Cox multivariate analysis for PFS.
| Factor | Variable | n | PFS (median) months | Hazard ratioa | 95% CI | P |
|---|---|---|---|---|---|---|
| Köhne | Low | 26 | 15 | 1.0 | Reference | 0.009 |
| Intermediate | 28 | 9.8 | 2.5 | 1.2–5.1 | ||
| High | 6 | 3.2 | 15.9 | 4.3–59.1 | ||
| CAb | No | 30 | 6.5 | 10.7 | 4.6–25.1 | 0.001 |
| Yes | 28 | 16.8 | 1.0 | Reference | ||
| GSTP1 | AA | 20 | 6.3 | 2.6 | 1.3–5.4 | 0.008 |
| AG+GG | 40 | 12.7 | 1.0 | Reference |
Abbreviations: CI=confidence interval; GSTP1=glutathione-S-transferase Pi; HR=hazard ratio; PFS=progression-free survival.
a
HR adjusted by significant genotypes (univariate analysis), Köhne classification.
b
Consolidation approach after triplet treatment.