Table 6.

Insulin receptor pathway related genes up regulated in ER- breast cancer cells in response to AA

Symbol	Entrez gene name	Fold change
ADIPOQ	adiponectin, C1Q and collagen domain containing	3.4
BTK	Bruton agammaglobulinemia tyrosine kinase	54.9
CDK2	cyclin-dependent kinase 2	2.4
CSF3R	colony stimulating factor 3 receptor (granulocyte)	2.1
CTGF	connective tissue growth factor	2.1
CTSD	cathepsin D	2.2
ESR2	estrogen receptor 2 (ER beta)	2.5
GRB2	growth factor receptor-bound protein 2	2.3
HAS2	hyaluronan synthase 2	2.0
HBEGF	heparin-binding EGF-like growth factor	2.0
IGHM	immunoglobulin heavy constant mu	2.4
IL4	interleukin 4	3.1
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	2.5
INSR	insulin receptor	43.5
IRF4	interferon regulatory factor 4	2.1
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	4.6
LIFR	leukemia inhibitory factor receptor alpha	2.5
LOX	lysyl oxidase	2.3
LTA	lymphotoxin alpha (TNF superfamily, member 1)	2.0
LTB	lymphotoxin beta (TNF superfamily, member 3)	2.0
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	2.1
NRG1	neuregulin 1	4.5
NTF3	neurotrophin 3	2.5
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	3.5
PTEN	phosphatase and tensin homolog	2.3
RCAN1	regulator of calcineurin 1	2.9
SMAD4	SMAD family member 4	3.7
SOD2	superoxide dismutase 2, mitochondrial	3.8
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	2.4
TRAF4	TNF receptor-associated factor 4	2.2
VEGFA	vascular endothelial growth factor A	2.5
VPREB1	pre-B lymphocyte 1	4.5