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The immunohistochemical profile of patient A103 demonstrates a strong diffuse immunoreactivity for EGFR wild type, b 30% reactivity for PTEN that correlates with PTEN loss; c negative reactivity for EGFRvIII, d diffuse reactivity for pAKT, and e rare cells exhibiting pS6 immunoreactivity with a positive internal neuronal control (arrow). The internal bar represents 50 microns
