Table 2.
Number of patients with grade ≥2 adverse events
| Toxicity grade | 2 | 3 | 4 | |||
|---|---|---|---|---|---|---|
| Stratum1 | A | B | A | B | A | B |
| Number of patients | 24 | 8 | 24 | 8 | 24 | 8 |
| Anemia | 1 (4) | 0 | 0 | 0 | 0 | 0 |
| Anorexia | 2 (8) | 1 (13) | 0 | 0 | 0 | 0 |
| Creatinine elevation | 0 | 0 | 0 | 1 (13) | 0 | 0 |
| Diarrhea | 5 (21) | 5 (63) | 0 | 0 | 0 | 0 |
| Fatigue | 3 (9) | 4 (50) | 2 (8) | 0 | 0 | 0 |
| Hypercholesterolemia | 4 (17) | 0 | 0 | 0 | 0 | 0 |
| Hypertriglyceridemia | 3 (13) | 0 | 1 (4) | 0 | 0 | 0 |
| Hypoalbuminemia | 3 (13) | 0 | 0 | 0 | 0 | 0 |
| Hypocalcemia | 1 (4) | 0 | 0 | 0 | 0 | 0 |
| Hypokalemia | 1 (4) | 0 | 1 (4) | 0 | 0 | 0 |
| Hypophosphatemia | 0 | 0 | 1 (4) | 0 | 0 | 0 |
| Infection | 2 (8) | 1 (13) | 1 (4) | 0 | 0 | 0 |
| Mucositis | 5 (21) | 4 (50) | 2 (8) | 0 | 0 | 0 |
| Nausea/emesis | 2 (8) | 1 (13) | 0 | 0 | 0 | 0 |
| Neutropenia | 1 (4) | 0 | 1 (4) | 0 | 0 | 0 |
| Rash | 7 (29) | 5 (63) | 6 (25) | 1 (13) | 0 | 0 |
| Thrombocytopenia | 0 | 1 (13) | 2 (8) | 1 (13) | 1 (4) | 0 |
| Transaminase elevation | 0 | 0 | 0 | 1 (13) | 0 | 0 |
| Weight loss | 1 (4) | 0 | 0 | 0 | 0 | 0 |
Numbers in parentheses refer to percentages
1
Stratum A: Patients not on CYP3A-inducing anti-epileptics (EIA-EDS) including phenytoin, carbamazepine, phenobarbitol, oxcarbazepine and primidone
Stratum B: Patients on EIAEDs