Table 2. Survival without relapse on drug and placebo for subjects in remission after (a) 12 weeks acute treatment for depression with drug; and (b) 12 weeks acute treatment plus 14 weeks of maintenance with drug, total of 6 months.
pp1 | (a) 14 weeks survival after 12 weeks of acute treatment | (b) 12 weeks survival after 6 months of treatment | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Randomized to Drug | Randomized to Placebo | Log-Rank test | Randomized to Drug | Randomized to Placebo | Log-Rank test | |||||
Total | Relapse | Total | Relapse | p | Total | Relapse | Total | Relapse | p | |
k = 7 | ||||||||||
1 | 65 | 11 | 12 | 7 | .0007 | 20 | 5 | 13 | 5 | .2912 |
2 | 4 | 1 | 2 | 0 | .6171 | 1 | 0 | 1 | 0 | 1 |
3 | 101 | 29 | 45 | 21 | .0020 | 38 | 5 | 17 | 9 | .0009 |
4 | 69 | 5 | 21 | 9 | .0333 | 24 | 5 | 12 | 2 | .9597 |
5 | 34 | 9 | 9 | 4 | .1385 | 14 | 4 | 4 | 0 | .3614 |
6 | 23 | 5 | 7 | 1 | .6487 | 7 | 2 | 5 | 2 | .6693 |
7 | 3 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | ||
k = 6 | ||||||||||
1 | 56 | 10 | 10 | 4 | .0325 | 16 | 3 | 12 | 5 | .1108 |
2 | 109 | 31 | 44 | 22 | .0007 | 41 | 8 | 18 | 8 | .0312 |
3 | 56 | 12 | 22 | 8 | .1510 | 19 | 3 | 11 | 2 | .8149 |
4 | 64 | 16 | 15 | 6 | .0779 | 25 | 6 | 10 | 3 | .2843 |
5 | 4 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
6 | 10 | 3 | 4 | 2 | .2924 | 3 | 2 | 0 | 0 | |
k = 5 | ||||||||||
1 | 82 | 24 | 32 | 14 | .0524 | 27 | 5 | 14 | 5 | .1741 |
2 | 13 | 2 | 2 | 0 | .6889 | 6 | 1 | 3 | 0 | .4795 |
3 | 18 | 5 | 3 | 2 | .0753 | 5 | 2 | 2 | 2 | .3459 |
4 | 104 | 22 | 36 | 14 | .0138 | 35 | 7 | 17 | 5 | .3892 |
5 | 82 | 19 | 23 | 12 | .0004 | 32 | 7 | 16 | 7 | .0204 |
k = 4 | ||||||||||
1 | 73 | 18 | 18 | 8 | .0286 | 27 | 7 | 13 | 5 | .1514 |
2 | 8 | 1 | 2 | 0 | .7237 | 4 | 1 | 1 | 0 | .6171 |
3 | 71 | 14 | 15 | 8 | .0032 | 20 | 6 | 14 | 5 | .6212 |
4 | 147 | 40 | 61 | 26 | .0021 | 54 | 8 | 24 | 8 | .0239 |