Table 1.

Stratification of ALL risk groups.

Adverse prognostic characteristics
Age >30 years Peripheral white blood cell count >30,000/µL Presence of adverse cytogenetics: t(9;22) t(4;11) t(1;19) Complex cytogenetics (>2 abnormalities) Residual leukemia on the day 28 bone marrow biopsy following induction chemotherapy
Low risk ALL	Intermediate risk ALL	High risk ALL
No adverse prognostic characteristics	Does not meet criteria for low risk ALL	Does not meet criteria for low or intermediate risk ALL
	AND	OR
	≥ 1 adverse prognostic characteristic	Presence of any adverse cytogenetics
	BUT	OR
	No adverse cytogenetics	Day 28 bone marrow biopsy with persistent leukemia
Treatment by risk group
Standard BFM regimen	Age <50 years: Augmented BFM regimen	Augmented BFM regimen
	Age ≥50 years: Standard BFM regimen