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l-NAME, AMT, and TRIM significantly inhibit the in vitro rat eosinophil migration induced by LTB4 (10−8 M) compared with control values (MEM; solid bar). Each of these compounds was used at concentrations of 0.1 (open bars) and 1.0 (crosshatched bars) mM. Each experiment was carried out in triplicate. Eosinophil migration is expressed as the mean number of migrated cells per HPF. The results are shown as the mean ± SEM (n = 3). ∗, P < 0.05 compared with the control value.
