. Author manuscript; available in PMC: 2011 Feb 1.

Published in final edited form as: Parkinsonism Relat Disord. 2009 Aug 31;16(2):109–111. doi: 10.1016/j.parkreldis.2009.08.006

Table 2.

Frequency and statistical analysis of LINGO1 rs9652490 in Parkinson disease and essential tremor series. Sample sizes given for each genotype account for genotyping failure.

Discovery		North America
	rs9652490	Controls		PD				ET
	Genotype	n	freq	n	freq	P-value	OR (95%CI)	n	freq	P-value	OR (95%CI)
	A/A	229	0.574	238	0.579	0.0117	2.1 (1.1–3.8)	215	0.609	0.0145	2.2 (1.1–4.2)
	A/G	137	0.343	156	0.380			124	0.351
	G/G	33	0.083	17	0.041			14	0.040
Replication		Norway
	rs9652490	Controls		PD
	Genotype	n	freq	n	freq	P-value	OR (95%CI)
	A/A	332	0.575	318	0.547	0.0078	1.7 (1.0–2.7)
	A/G	200	0.347	235	0.404
	G/G	45	0.078	28	0.048
Meta-analysis
	rs9652490	Controls		Combined PD				Combined PD and ET
	Genotype	n	freq	n	freq	P-value	OR (95%CI)	n	freq	P-value	OR (95%CI)
	A/A	561	0.575	556	0.560	3.4x10⁻⁴	1.8 (1.3–2.7)	771	0.573	1.3x10⁻⁴	1.9 (1.3–2.7)
	A/G	337	0.345	391	0.394			515	0.383
	G/G	78	0.080	45	0.045			59	0.044