Skip to main content
. Author manuscript; available in PMC: 2010 Mar 23.
Published in final edited form as: Nat Rev Neurosci. 2009 Jun;10(6):459–466. doi: 10.1038/nrn2632

Figure 3. Subcellular localization of stress-mediator receptors.

Figure 3

The actions of different stress mediators on a single neuron are orchestrated through the distinct subcellular localization of the relevant receptors. This is illustrated in this cartoon of a hypothetical pyramidal cell (which includes features that exist on either or both CA3 and CA1 principal cells). For example, corticotropin-releasing hormone receptor 1 (CRHR1) is located in somata as well as on dendrites and dendritic spines3,39,48,56, whereas CRHR2 seems to reside on the axon initial segment (Y. Chen, personal communication). In addition, monoamine receptors that terminate on hippocampal pyramidal cells reside on specific dendritic domains57,58. Note that the subcellular distribution patterns of each receptor might differ between brain areas. For instance, glucocorticoid receptors (GRs) might be present on postsynaptic (dendritic) domains in certain amygdala neurons59. 5-HT, 5-hydroxytryptamine; MR, mineralocorticoid receptors; NA, noradrenaline.