Table 1.

Effects of α-syn monomer and oligomers extracted from different brain regions of A53T and WT α-syn transgenic mice on the kinetics of recombinant α-syn fibril formation in vitro

Brain region/fraction	RFU (ThioT)
α-syn alone	181.1 ± 9.8
α-syn + A53T SC 53Å oligomer	223.5 ± 8.7*
α-syn + A53T SC monomer	159.0 ± 10.7
α-syn + A53T OB 53Å oligomer	136.8 ± 11.3*
α-syn + A53T OB monomer	156.8 ± 18.1
α-syn + WT SC 53Å fraction	187.4 ± 11.3
α-syn + WT OB 53Å fraction	182.8 ± 5.3

The values represent the mean ± SEM (n = 4–6). Fluorescence intensity was recorded after 24 h incubation.

*p < 0.05, Student's t test analysis compared with purified recombinant α-syn protein alone. RFU, Relative fluorescence units.