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Aged interleukin-6 (IL-6) knockout mice are more resistant to lipopolysaccharide (LPS)-induced endotoxemia. Survival of IL-6(–/–) (closed squares) and wild-type control mice (open diamonds) was monitored for 7 days after LPS injection (5 mg/kg, intraperitoneal). All mice were 26-month-old females with C57BL/6 genetic background (n = 8 each group).
