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. 2009 Dec 26;285(10):6879–6890. doi: 10.1074/jbc.M109.080416

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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SCHEME 1. — Gating of mitochondrial PTP by LCFA/MEDICA. Suppression of Raf1 expression by LCFA/MEDICA-induced UPR is proposed to result in inhibition of both the Raf1/MEK/ERK/RSK1 and the Raf1/adenylate cyclase/PKA transduction pathways. Suppression of RSK1 and PKA may result in decreased mitochondrial P-Bad(Ser-112) and P-Bad(Ser-155), respectively. Mitochondrial nonphosphorylated Bad(Ser-112, Ser-155) may bind to Bcl2 resulting in displacement of Bax or Bak. Increased mitochondrial Bax or Bak may induce LC-PTP gating and calorigenesis that may drift to HC-PTP gating and apoptosis.

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