FIGURE 2.

The inhibited complex I activity in brains of A53T αS tg mice is independent of mouse age. Complex I activity was measured in purified mitochondria from brains of 1-, 8-, and 12–15-month-old wt and A53T αS tg mice (26) as in Fig. 1b. Relative complex I activity is normalized to wt control for each age group and is plotted as the percentage of activity ± S.D. Significant differences are detected between the two genotypes in the three age groups. No significant differences are detected between age groups in the same genotype (n = 6–8 mice in each age group for A53T αS and wt mice). *, p < 0.017 analysis of variance for multiple pair comparison.