Figure 4.

Effects of clozapine and ketanserin on 5HT- and oleamide-elicited cAMP responses in 5HT₇-transfected HeLa cells. cAMP values are expressed as stimulation over basal and represent the mean ± SEM of at least four experiments performed in triplicate. Clozapine (1 μM) and ketanserin (10 μM) were incubated with HeLa cells 30–45 min before addition of 5HT or oleamide. Asterisks indicate significant inhibition by clozapine and ketanserin using Student’s t test (one-tailed): ∗, P = 0.024–0.038; ∗∗, P = 0.005.