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. 2009 Dec 23;285(10):7670–7685. doi: 10.1074/jbc.M109.090175

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FIGURE 8. — Proposed metabolic model for the formation of two carboxylic acids HDOPA [III] and 20α-DHOPA [IV] from corticosterone [I] via its aldehyde hydrate [IIA] and putative intermediates corticosterone aldehyde [IIB], 21-gem-triol [IIC]. CYPs (a panel of CYPs, especially the major liver enzyme CYP3A subfamily, and the PPARα-induced CYP4A subfamily), ALDH (PPARα specific induced ALDH3A2, possibly coincided with other PPARα-induced ALDH family members), and 21-HSD (PPARα-induced AKR1C18, possibly coincided with PPARα-induced HSD17B) are involved in the multi-step oxidation.