Fig. 4.

Effects of quiescence and heterogeneity of LSCs on population sizes during therapy. Panel A: ϕ_L = 0.007 << ϕ_H = 0.21, and ν_L = ν_H = 0.00024 week⁻¹. The coefficient of variation of population size increases as stem cell counts approach very small numbers, with ranges from 0.17 to 1.2 for LSCs, 0.03 to 0.11 for HSCs, 0.04 to 0.44 for qLSCs, and 0.03 to 0.17 for qHSCs. Panel B: ϕ_L = ϕ_H = 0.007, and ν_L = ν_H = 0.00024 week⁻¹. Panel C: ϕ_L = ϕ_H = 0.007, ν_L = 0.25, and ν_H = 0.00024 week⁻¹. In panels A to C, δ_L = 0.59, δ_H = 0.08, β_L = β_H = 0.024, and α_L = α_H = 0.07 week⁻¹. Panel D: Arrow represents increasing δ_H. In all cases, δ₄ = 0.52, δ₃ = 0.57, δ₂ = 0.62, δ₁ = 0.67. Model 1: δ_H = 0.08 week⁻¹. Model 2: δ_H = 0.31 week⁻¹. Model 3: δ_H = 0.48 week⁻¹.