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. Author manuscript; available in PMC: 2010 Mar 23.
Published in final edited form as: Nat Immunol. 2005 Jan 9;6(2):181–188. doi: 10.1038/ni1156

Figure 1.

Figure 1

Resistance to NK cell attack maps to the HCMV UL/b′ sequence. (a,b) Human fetal foreskin fibroblasts (HFFFs) were mock infected (Mock) or were infected for 72 h with HCMV strains AD169, Toledo, Merlin or 6397 or a strain AD169ΔUL40 deletion mutant (multiplicity of infection, 10). NKL cells were used as effectors in allogeneic chromium release assays. (c) HFFFs were infected with strains AD169, Towne, Toledo or the recombinant virus Towne/Tol11 1.1 (T/T11 1.1) and NKLs were used as effectors in allogeneic NK cell assays. (d) Autologous assay with D9SF targets (primary skin fibroblast from donor 9) infected as described in c with IFN-α-activated bulk cultures derived from D9 PBMCs (D9NKb) as effectors. Results are mean ± s.d. of triplicate or quadruplicate cultures and are representative of at least three and up to eight independent experiments. E:T, effector:target ratio.