Table 5.
Comparison of intra- and peritumor lymphocyte populations within SCCs from KTRs and non-KTRs
| Parameter | Peritumor Infiltrate (Median [Range]) | Intratumor Infiltrate (Median [Range]) | P |
|---|---|---|---|
| KTR SCC (n = 14) | |||
| FOXP3+ cells (0.25 mm2) | 70 (27 to 264) | 60 (13 to 155) | 0.011 |
| CD8+ cells (0.25 mm2) | 102 (50 to 449) | 24 (2 to 153) | <0.001 |
| CD8/FOXP3 | 1.46 (0.70 to 4.00) | 0.54 (0.01 to 2.50) | <0.001 |
| CD56+ cells (0.25 mm2) | 13 (0 to 43) | 5 (1 to 14) | 0.003 |
| Non-KTR SCC (n = 11) | |||
| FOXP3+ cells (0.25 mm2) | 65 (34 to 280) | 67 (25 to 434) | 0.637 |
| CD8+ cells (0.25 mm2) | 148 (54 to 377) | 53 (17 to 191) | 0.001 |
| CD8/FOXP3 | 1.57 (0.80 to 6.10) | 0.89 (0.30 to 2.60) | 0.001 |
| CD56+ cells (0.25 mm2) | 14 (2 to 115) | 4 (1 to 60) | 0.001 |
Fourteen KTR SCCs and 11 non-KTR SCCs had both intra- and peritumor infiltrate as defined in the Concise Methods section. Comparison of the median density of infiltrate for each cell type between the two regions was compared for each individual tumor by Wilcoxon sign rank test (two-tailed).