Figure 5.

B cell deficiency increases tubular proliferation in postischemic kidneys during the repair phase. (A) Tubular proliferative index in postischemic kidneys. The tubular proliferative index of postischemic kidneys was highest on day 3 after IRI in all groups and decreased over time (n = 5 to 8 per group). (B) Ki-67 immunohistochemistry of renal cortex. The tubular proliferative index of μMT mice was higher than both control and B cell–transferred μMT mice in the cortex throughout the repair phase and also in the medulla on days 3 and 10 after IRI. The cells stained reddish-brown represent Ki-67–positive cells, which reflect the proliferation process. μMT-B mice were μMT mice that underwent adoptive B cell transfer on day 1 after renal IRI. *P < 0.05 versus control mice; **P < 0.001 versus control mice. Magnification, ×200.