Figure 1.

Glomerular gene expression profiles linearly changed with aging. Rats were fed an ad libitum diet (left) or a calorie-restricted diet (right). Note that some gene expression profiles was linearly increased during aging (e.g., Pnoc, ceruloplasmin, or VCAM), and some were linearly decreased during aging (e.g., thrombomodulin or nephrin). In some cases, calorie restriction blunted or prevented changes in gene expression with aging (e.g., ceruloplasmin or nephrin). A control gene GAPDH, which does not change with age, is shown at the bottom. The gene lists for all genes identified as changing linearly with age are shown in Supplemental Tables 1A and 1B.