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. 2010 Mar 9;123(7):1116–1123. doi: 10.1242/jcs.058958

Fig. 1.

Fig. 1.

FRG1 is highly conserved evolutionarily. The deduced amino acid sequence alignment of FRG1 homologs using ClustalW shows that human FRG1 is 97% identical to the mouse protein, 81% identical to Xenopus and 42% identical to C. elegans. Green residues are conserved in all four species; yellow residues are similar in all four species; unshaded residues are not conserved. Putative domains characterized for human FRG1 are shown above. The predicted C. elegans NLS is underlined. The peptide used to generate the FRG-1 antibody is in the blue box.