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Proposed model for the role of PALB2 in linking MRG15 and the BRCA complex into a pathway of HR. We propose that by directly binding PALB2, BRCA1 and MRG15 independently regulate site selection and chromatin accessibility, respectively, in PALB2 recruitment to sites of DNA damage. Once it is localized, PALB2 is proposed to be responsible for the recruitment of BRCA2 and RAD51.
