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. 2010 Mar 24;5(3):e9843. doi: 10.1371/journal.pone.0009843

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Jean-marie Billard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, top. Superimposed sample traces of evoked fEPSPs induced by the electrical stimulation of glutamatergic afferents in the stratum radiatum of an adult (left) and aged Sprague-Dawley rat (right) before (1) and 40 min after LFS induction (2). A, bottom. Averaged LTD expressed as percent change in the slope of fEPSP vs. time, recorded in aCSF with a Ca²⁺/Mg²⁺ ratio of >1.5 in slices from adult (n = 32) and aged (n = 27) animals. Note that LTD is comparable in the two groups of animals. B. Comparison of LTD magnitude averaged from the last 10 min of recordings in adult and aged Sprague-Dawley rats as a function of the interval between slice isolation and LFS delivery (** p<0.01). Note an age-related decrease in LTD expression in slices that have rested for 3 to 5 h, which is not observed at longer delays.