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. 2010 Mar 24;5(3):e9843. doi: 10.1371/journal.pone.0009843

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Jean-marie Billard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Averaged LTD expressed as percent change in the slope of fEPSP vs. time, recorded in slices from adult (n = 26) and aged (n = 23) Sprague-Dawley rats in the presence of the NMDA-R antagonist d-APV (80 µM). Note that d-APV prevents LTD expression in both groups of animals. B. Comparison of LTD expression as a function of the interval between slice isolation and LFS delivery in the two groups of animals in the presence of d-APV.